Forschung

Forschungs- und Kooperationsprojekte (Auszug)

Die NGS-Einheit ist Partner in verschiedenen Forschungsprojekten und Verbünden. Schwerpunkte sind die molekularbiologische Charakterisierung von Nukleinsäuren und deren Modifikationen, sowie die Anwendung innovativer Sequenzierungstechnologien wie bspw. Nanopore Sequencing.

  • Target-H - Innovative Therapien, smarte Diagnostik und prädiktive oxidative Signalmuster am Beispiel von Hautkrebs (Verbundprojekt der Landesexzellenzinitiative MV)
  • Charakterisierung nativer Basen-Modifikationen (DNA/RNA) - Nanopore Sequenzierung: Beeinflussung der Modifizierung auf epigenetischer und epitranskriptomischer Ebene durch Azacitidin an leukämischen Tumormodellen in Kooperation mit Prof. Wohlers (Data Science in der Lungenforschung, Forschungszentrum Borstel), Dr. Reinberger (Institut für Kardiogenetik, Universität zu Lübeck) und Prof. Junghanß/Dr. Richter (Klinik für Hämatologie und Onkologie, Universitätsmedizin Rostock))
  • Charakterisierung zell- und molekularbiologischer Effekte von neuen Wirkstoff-Kandidaten - Kooperation mit dem Institut für Chemie (AG Organische Chemie, Universität Rostock), Lehrstuhl Systembiologie & Bioinformatik (Universität Rostock) und dem Leibniz-Institut für Katalyse (Rostock)
  • Comparative Genomics - Vergleichende Genetik onkologischer Erkrankungen verschiedener Spezies (Hund, Pferd, etc.). Kooperationspartner: Stiftung Tierärztliche Hochschule Hannover, Veterinärmedizinische Universität Wien, Technische Universität Graz, European Canine Lymphoma Network (ECLN), u.a.

 

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Publikationen der letzten 5 Jahre

A Gázquez-Gutiérrez, P Chin, G Peris, K Gordon, PG Marchante, J Witteveldt, P Tristán-Ramos, JO Rouvière, LI Knol, A Ivens, L López-Onieva, A Estevez, W Garland, TH Jensen, SR Heras, S Macias. Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8. bioRxiv 2025.05.28.656609; doi: 10.1101/2025.05.28.656609

Lainscsek X, Kong W, Rütgen BC, Beck J, Brenig B, Nolte I, Murua Escobar H, Taher L. Transcriptomic profiling in canine B-cell lymphoma supports a synergistic effect of BTK and PI3K inhibitors. Front Vet Sci. 2025 Apr 25;12:1577028. doi: 10.3389/fvets.2025.1577028

Baumann AA, Knol LI, Arlt M, Hutschenreiter T, Richter A, Widmann TJ, Franke M, Hackmann K, Winkler S, Richter D, Spier I, Aretz S, Aust D, Porrmann J, William D, Schröck E, Glimm H, Jahn A. Long-read genome and RNA sequencing resolve a pathogenic intronic germline LINE-1 insertion in APC. NPJ Genom Med. 2025 Apr 4;10(1):30. doi: 10.1038/s41525-025-00485-5

Möhrmann L, Werner M, Oleś M, Knol L, Arnold JS, Mundt T, Paramasivam N, Richter D, Fröhlich M, Hutter B, Hüllein J, Jahn A, Scheffold C, Möhrmann EE, Hanf D, Kreutzfeldt S, Heilig CE, Teleanu MV, Lipka DB, Beck K, Baude-Müller A, Jelas I, Rieke DT, Klotz LV, Shah R, Herold T, Boerries M, Illert AL, Allgäuer M, Stenzinger A, Kerle IA, Horak P, Heining C, Schröck E, Hübschmann D, Fröhling S, Glimm H. Comprehensive genomic and transcriptomic analysis enables molecularly guided therapy options in peritoneal and pleural mesothelioma. ESMO Open. 2025 Apr;10(4):104532. doi: 10.1016/j.esmoop.2025.104532

Colomer-Boronat A, Knol LI, Peris G, Sanchez L, Peluso S, Tristan-Ramos P, Gazquez-Gutierrez A, Chin P, Gordon K, Barturen G, Hill RE, Sanchez-Luque FJ, Garcia-Perez JL, Ivens A, Macias S, Heras SR. DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects. Nucleic Acids Res. 2025 Mar 20;53(6):gkaf197. doi: 10.1093/nar/gkaf197

Brock L, Benzien L, Lange S, Huehns M, Runge A, Roolf C, Sekora A, Knuebel G, Murua Escobar H, Junghanss C, Richter A. KMT2A degradation is observed in decitabine-responsive acute lymphoblastic leukemia cells. Mol Oncol. 2025 Jan 4. doi: 10.1002/1878-0261.13792

Gutierrez-Riquelme T, Karkossa I, Schubert K, Liebscher G, Packeiser EM, Nolte I, von Bergen M, Murua Escobar H, Aguilera-Rojas M, Einspanier R, Stein T. Proteomic analysis of extracellular vesicles derived from canine mammary tumour cell lines identifies protein signatures specific for disease state. BMC Vet Res. 2024 Oct 26;20(1):488. doi: 10.1186/s12917-024-04331-1

Palmer D, Henze L, Murua Escobar H, Walter U, Kowald A, Fuellen G. Multicohort study testing the generalisability of the SASKit-ML stroke and PDAC prognostic model pipeline to other chronic diseases. BMJ Open. 2024 Sep 30;14(9):e088181. doi: 10.1136/bmjopen-2024-088181

He X, Gao Y, Deng Y, He J, Nolte I, Murua Escobar H, Yu F. The Comparative Oncology of Canine Malignant Melanoma in Targeted Therapy: A Systematic Review of In Vitro Experiments and Animal Model Reports. Int J Mol Sci. 2024 Sep 26;25(19):10387. doi: 10.3390/ijms251910387

Gao YU, Wendt S, Krohn S, Alammar M, Junghanss C, Nolte I, Escobar HM. Evaluation of Pan-RAF Inhibitor LY3009120 on Human Uveal Melanoma Cell Line 92-1. Anticancer Res. 2024 Sep;44(9):3843-3848. doi: 10.21873/anticanres.17210

Vasilatis DM, Batra N, Lucchesi CA, Abria CJ, Packeiser EM, Murua Escobar H, Ghosh PM. Alterations in Tumor Aggression Following Androgen Receptor Signaling Restoration in Canine Prostate Cancer Cell Lines. Int J Mol Sci. 2024 Aug 7;25(16):8628. doi: 10.3390/ijms25168628

Schäfer TE, Knol LI, Haas FV, Hartley A, Pernickel SCS, Jády A, Finkbeiner MSC, Achberger J, Arelaki S, Modic Ž, Schröer K, Zhang W, Schmidt B, Schuster P, Haferkamp S, Doerner J, Gebauer F, Ackermann M, Kvasnicka HM, Kulkarni A, Bots STF, Kemp V, Hawinkels LJAC, Poetsch AR, Hoeben RC, Ehrhardt A, Marchini A, Ungerechts G, Ball CR, Engeland CE. Biomarker screen for efficacy of oncolytic virotherapy in patient-derived pancreatic cancer cultures. EBioMedicine. 2024 Jul;105:105219. doi: 10.1016/j.ebiom.2024.105219

Schulz B, Leitner E, Schreiber T, Lindner T, Schwarz R, Aboutara N, Ma Y, Murua Escobar H, Palme R, Hinz B, Vollmar B, Zechner D. Sex Matters-Insights from Testing Drug Efficacy in an Animal Model of Pancreatic Cancer. Cancers (Basel). 2024 May 16;16(10):1901. doi: 10.3390/cancers16101901

Hobeck AD, Wendt S, Krohn S, Knuebel G, Bartels S, Schipper E, Junghanss C, Murua Escobar H. Comparative Analyses of Targeted Myeloid Cancer Next-Generation Sequencing Panel in Fresh Blood, Bone Marrow and FFPE Material. Int J Mol Sci. 2024 Mar 21;25(6):3534. doi: 10.3390/ijms25063534

Gao Y, Packeiser EM, Wendt S, Sekora A, Cavalleri JV, Pratscher B, Alammar M, Hühns M, Brenig B, Junghanss C, Nolte I, Murua Escobar H. Cross-Species Comparison of the Pan-RAF Inhibitor LY3009120's Anti-Tumor Effects in Equine, Canine, and Human Malignant Melanoma Cell Lines. Genes (Basel). 2024 Feb 3;15(2):202. doi: 10.3390/genes15020202

Henze L, Grunwald L, Felser S, Witte M, Grosse-Thie C, Roolf C, Murua Escobar H, Junghanss C. Abdominal venous thromboses: detection of the JAK2 p.V617F mutation by next-generation ultradeep sequencing-A prevalence study of patients in Mecklenburg-West Pomerania (2017-2021). Front Med (Lausanne). 2024 Jan 11;10:1344769. doi: 10.3389/fmed.2023.1344769

Ladwig A, Gupta S, Ehlers P, Sekora A, Alammar M, Koczan D, Wolkenhauer O, Junghanss C, Langer P, Murua Escobar H. Exploring Thiazolopyridine AV25R: Unraveling of Biological Activities, Selective Anti-Cancer Properties and In Silico Target and Binding Prediction in Hematological Neoplasms. Molecules. 2023 Dec 15;28(24):8120. doi: 10.3390/molecules28248120

Fibi-Smetana S, Inglis C, Schuster D, Eberle N, Granados-Soler JL, Liu W, Krohn S, Junghanss C, Nolte I, Taher L, Murua Escobar H. The TiHoCL panel for canine lymphoma: a feasibility study integrating functional genomics and network biology approaches for comparative oncology targeted NGS panel design. Front Vet Sci. 2023 Dec 8;10:1301536. doi: 10.3389/fvets.2023.1301536

Efendic F, Krohn S, Murua Escobar H, Venkateswaran S, Bennett SAL, Hermann A, Frech MJ. Generation of the human iPSC lines AKOSi011-A carrying the mutation p.Pro65Ser/p.Asp35T and AKOSi012-A, carrying the mutation p.Tyr231His, derived from FAHN patient fibroblasts. Stem Cell Res. 2023 Sep;71:103178. doi: 10.1016/j.scr.2023.103178

Yi Z, Gao Y, Yu F, Zhu Y, Liu H, Li J, Murua Escobar H. Interventions for treatment of cutaneous melanoma in horses: a structured literature review. Vet Res Commun. 2023 Jun;47(2):347-360. doi: 10.1007/s11259-022-10023-8

Packeiser EM, Engels L, Nolte I, Goericke-Pesch S, Murua Escobar H. MDR1 Inhibition Reverses Doxorubicin-Resistance in Six Doxorubicin-Resistant Canine Prostate and Bladder Cancer Cell Lines. Int J Mol Sci. 2023 May 2;24(9):8136. doi: 10.3390/ijms24098136

Revskij D, Runst J, Umstätter C, Ehlers L, Rohde S, Zechner D, Bastian M, Müller-Hilke B, Fuellen G, Henze L, Murua Escobar H, Junghanss C, Kowald A, Walter U, Köhling R, Wolkenhauer O, Jaster R. Uncoupling protein 2 deficiency of non-cancerous tissues inhibits the progression of pancreatic cancer in mice. Hepatobiliary Pancreat Dis Int. 2023 Apr;22(2):190-199. doi: 10.1016/j.hbpd.2022.12.003

Waad Sadiq Z, Brioli A, Al-Abdulla R, Çetin G, Schütt J, Murua Escobar H, Krüger E, Ebstein F. Immunogenic cell death triggered by impaired deubiquitination in multiple myeloma relies on dysregulated type I interferon signaling. Front Immunol. 2023 Mar 2;14:982720. doi: 10.3389/fimmu.2023.982720

Holz C, Lange S, Sekora A, Knuebel G, Krohn S, Murua Escobar H, Junghanss C, Richter A. Combined BCL-2 and PI3K/AKT Pathway Inhibition in KMT2A-Rearranged Acute B-Lymphoblastic Leukemia Cells. Int J Mol Sci. 2023 Jan 10;24(2):1359. doi: 10.3390/ijms24021359

Nilson SM, Gandolfi B, Grahn RA, Kurushima JD, Lipinski MJ, Randi E, Waly NE, Driscoll C, Murua Escobar H, Schuster RK, Maruyama S, Labarthe N, Chomel BB, Ghosh SK, Ozpinar H, Rah HC, Millán J, Mendes-de-Almeida F, Levy JK, Heitz E, Scherk MA, Alves PC, Decker JE, Lyons LA. Genetics of randomly bred cats support the cradle of cat domestication being in the Near East. Heredity (Edinb). 2022 Dec;129(6):346-355. doi: 10.1038/s41437-022-00568-4

Granados-Soler JL, Taher L, Beck J, Bornemann-Kolatzki K, Brenig B, Nerschbach V, Ferreira F, Junginger J, Hewicker-Trautwein M, Murua Escobar H, Nolte I. Transcription profiling of feline mammary carcinomas and derived cell lines reveals biomarkers and drug targets associated with metabolic and cell cycle pathways. Sci Rep. 2022 Oct 11;12(1):17025. doi: 10.1038/s41598-022-20874-5

Sender S, Sultan AW, Palmer D, Koczan D, Sekora A, Beck J, Schuetz E, Taher L, Brenig B, Fuellen G, Junghanss C, Murua Escobar H. Evaluation of the Synergistic Potential of Simultaneous Pan- or Isoform-Specific BET and SYK Inhibition in B-Cell Lymphoma: An In Vitro Approach. Cancers (Basel). 2022 Sep 27;14(19):4691. doi: 10.3390/cancers14194691

Klose K, Packeiser EM, Granados-Soler JL, Hewicker-Trautwein M, Murua Escobar H, Nolte I. Evaluation of the therapeutic potential of masitinib and expression of its specific targets c-Kit, PDGFR-α, PDGFR-β, and Lyn in canine prostate cancer cell lines. Vet Comp Oncol. 2022 Sep;20(3):641-652. doi: 10.1111/vco.12817

Ma Y, Schulz B, Trakooljul N, Al Ammar M, Sekora A, Sender S, Hadlich F, Zechner D, Weiss FU, Lerch MM, Jaster R, Junghanss C, Murua Escobar H. Inhibition of KRAS, MEK and PI3K Demonstrate Synergistic Anti-Tumor Effects in Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2022 Sep 14;14(18):4467. doi: 10.3390/cancers14184467

Efendic F, Völkner C, Krohn S, Murua Escobar H, Venkateswaran S, Bennett S, Hermann A, Frech MJ. Generation of the human iPSC line AKOSi010-A from fibroblasts of a female FAHN patient, carrying the compound heterozygous mutation p.Gly45Arg/p.His319Arg. Stem Cell Res. 2022 Aug;63:102863. doi: 10.1016/j.scr.2022.102863

Eichhorst A, Gallhof M, Voss A, Sekora A, Eggers L, Huyen LT, Junghanss C, Murua Escobar H, Brasholz M. Spirooxindol-1,3-oxazine Alkaloids: Highly Potent and Selective Antitumor Agents Evolved from Iterative Structure Optimization. ChemMedChem. 2022 Jul 19;17(14):e202200162. doi: 10.1002/cmdc.202200162

Gladbach YS, Sklarz LM, Roolf C, Beck J, Schütz E, Fuellen G, Junghanss C, Murua Escobar H, Hamed M. Molecular Characterization of the Response to Conventional Chemotherapeutics in Pro-B-ALL Cell Lines in Terms of Tumor Relapse. Genes (Basel). 2022 Jul 14;13(7):1240. doi: 10.3390/genes13071240

Richter A, Lange S, Holz C, Brock L, Freitag T, Sekora A, Knuebel G, Krohn S, Schwarz R, Hinz B, Murua Escobar H, Junghanss C. Effective tumor cell abrogation via Venetoclax-mediated BCL-2 inhibition in KMT2A-rearranged acute B-lymphoblastic leukemia. Cell Death Discov. 2022 Jul 1;8(1):302. doi: 10.1038/s41420-022-01093-3

Kowald A, Barrantes I, Möller S, Palmer D, Murua Escobar H, Schwerk A, Fuellen G. Transfer learning of clinical outcomes from preclinical molecular data, principles and perspectives. Brief Bioinform. 2022 May 13;23(3):bbac133. doi: 10.1093/bib/bbac133

Ma Y, Sender S, Sekora A, Kong W, Bauer P, Ameziane N, Krake S, Radefeldt M, Al-Ali R, Weiss FU, Lerch MM, Parveen A, Zechner D, Junghanss C, Murua Escobar H. Inhibitory Response to CK II Inhibitor Silmitasertib and CDKs Inhibitor Dinaciclib Is Related to Genetic Differences in Pancreatic Ductal Adenocarcinoma Cell Lines. Int J Mol Sci. 2022 Apr 16;23(8):4409. doi: 10.3390/ijms23084409

Ma Y, Sender S, Sekora A, Kong W, Bauer P, Ameziane N, Al-Ali R, Krake S, Radefeldt M, Weiss FU, Lerch MM, Parveen A, Zechner D, Junghanss C, Murua Escobar H. The Inhibitory Response to PI3K/AKT Pathway Inhibitors MK-2206 and Buparlisib Is Related to Genetic Differences in Pancreatic Ductal Adenocarcinoma Cell Lines. Int J Mol Sci. 2022 Apr 13;23(8):4295. doi: 10.3390/ijms23084295

Schwarz R, Richter A, Ito ERD, Murua Escobar H, Junghanß C, Hinz B. Validation of an LC-MS/MS Method for the Quantification of the CK2 Inhibitor Silmitasertib (CX-4945) in Human Plasma. Molecules. 2022 Apr 7;27(8):2394. doi: 10.3390/molecules27082394

Schaefer S, Lange S, Werner J, Machka C, Neumann K, Knuebel G, Vogel H, Lindner I, Glass Ä, Murua Escobar H, Nolte I, Junghanss C. Engraftment Effects after Intra-Bone Marrow versus Intravenous Allogeneic Stem Cell Transplantation in a Reduced-Intensity Conditioning Dog Leukocyte Antigen-Identical Canine Model. Transplant Cell Ther. 2022 Feb;28(2):70.e1-70.e5. doi: 10.1016/j.jtct.2021.11.010

Packeiser EM, Taher L, Kong W, Ernst M, Beck J, Hewicker-Trautwein M, Brenig B, Schütz E, Murua Escobar H, Nolte I. RNA-seq of nine canine prostate cancer cell lines reveals diverse therapeutic target signatures. Cancer Cell Int. 2022 Feb 2;22(1):54. doi: 10.1186/s12935-021-02422-9

Schwarz R, Seiler ERD, Sender S, Pews-Davtyan A, Murua Escobar H, Zechner D, Beller M, Junghanß C, Hinz B. A Simple LC-MS/MS Method for the Quantification of PDA-66 in Human Plasma. Molecules. 2022 Feb 1;27(3):974. doi: 10.3390/molecules27030974

Alnajjar S, Nolte I, Schille JT, Sender S, Trakoolju N, Perez SV, Zechner D, Vollmar B, Junghanss C, Murua Escobar H. Establishment and Characterization of FusionRed Stable Transfected Canine Prostate Adenocarcinoma and Transitional Cell Carcinoma Cells. In Vivo. 2022 Jan-Feb;36(1):170-179. doi: 10.21873/invivo.12688

Richter A, Roolf C, Sekora A, Knuebel G, Krohn S, Lange S, Krebs V, Schneider B, Lakner J, Wittke C, Kiefel C, Jeremias I, Murua Escobar H, Vollmar B, Junghanss C. The Molecular Subtype of Adult Acute Lymphoblastic Leukemia Samples Determines the Engraftment Site and Proliferation Kinetics in Patient-Derived Xenograft Models. Cells. 2022 Jan 3;11(1):150. doi: 10.3390/cells11010150

Alnajjar S, Nolte I, Becker A, Schille JT, Trakooljul N, Frank M, Ngezahayo A, Murua Escobar H. Ablation of Red Stable Transfected Claudin Expressing Canine Prostate Adenocarcinoma and Transitional Cell Carcinoma Cell Lines by C-CPE Gold-Nanoparticle-Mediated Laser Intervention. Int J Mol Sci. 2021 Nov 13;22(22):12289. doi: 10.3390/ijms222212289

Kong W, Sender S, Taher L, Villa-Perez S, Ma Y, Sekora A, Ruetgen BC, Brenig B, Beck J, Schuetz E, Junghanss C, Nolte I, Murua Escobar H. BTK and PI3K Inhibitors Reveal Synergistic Inhibitory Anti-Tumoral Effects in Canine Diffuse Large B-Cell Lymphoma Cells. Int J Mol Sci. 2021 Nov 24;22(23):12673. doi: 10.3390/ijms222312673

Thiemeyer H, Taher L, Schille JT, Packeiser EM, Harder LK, Hewicker-Trautwein M, Brenig B, Schütz E, Beck J, Nolte I, Murua Escobar H. An RNA-Seq-Based Framework for Characterizing Canine Prostate Cancer and Prioritizing Clinically Relevant Biomarker Candidate Genes. Int J Mol Sci. 2021 Oct 25;22(21):11481. doi: 10.3390/ijms222111481

Klose K, Packeiser EM, Müller P, Granados-Soler JL, Schille JT, Goericke-Pesch S, Kietzmann M, Murua Escobar H, Nolte I. Metformin and sodium dichloroacetate effects on proliferation, apoptosis, and metabolic activity tested alone and in combination in a canine prostate and a bladder cancer cell line. PLoS One. 2021 Sep 27;16(9):e0257403. doi: 10.1371/journal.pone.0257403

Weiner F, Schille JT, Hein JI, Wu XF, Beller M, Junghanß C, Murua Escobar H, Nolte I. Evaluation of combination protocols of the chemotherapeutic agent FX-9 with azacitidine, dichloroacetic acid, doxorubicin or carboplatin on prostate carcinoma cell lines. PLoS One. 2021 Aug 25;16(8):e0256468. doi: 10.1371/journal.pone.0256468

Martens MC, Edelkamp J, Seebode C, Schäfer M, Stählke S, Krohn S, Jung O, Murua Escobar H, Emmert S, Boeckmann L. Generation and Characterization of a CRISPR/Cas9-Mediated SNAP29 Knockout in Human Fibroblasts. Int J Mol Sci. 2021 May 18;22(10):5293. doi: 10.3390/ijms22105293

Richter A, Fischer E, Holz C, Schulze J, Lange S, Sekora A, Knuebel G, Henze L, Roolf C, Murua Escobar H, Junghanss C. Combined Application of Pan-AKT Inhibitor MK-2206 and BCL-2 Antagonist Venetoclax in B-Cell Precursor Acute Lymphoblastic Leukemia. Int J Mol Sci. 2021 Mar 9;22(5):2771. doi: 10.3390/ijms22052771

Schaefer S, Lange S, Werner J, Machka C, Neumann K, Knuebel G, Vogel H, Lindner I, Glass Ä, Murua Escobar H, Nolte I, Junghanss C. Engraftment Effects after Intra-Bone Marrow versus Intravenous Allogeneic Stem Cell Transplantation in a Reduced-Intensity Conditioning Dog Leukocyte Antigen-Identical Canine Model. Transplant Cell Ther. 2022 Feb;28(2):70.e1-70.e5. doi: 10.1016/j.jtct.2021.11.010

Schille JT, Nolte I, Beck J, Jilani D, Roolf C, Pews-Davtyan A, Rolfs A, Henze L, Beller M, Brenig B, Junghanss C, Schütz E, Murua Escobar H. PDA Indolylmaleimides Induce Anti-Tumor Effects in Prostate Carcinoma Cell Lines Through Mitotic Death. Front Vet Sci. 2021 Jan 20;7:558135. doi: 10.3389/fvets.2020.558135

Sender S, Sekora A, Villa Perez S, Chabanovska O, Becker A, Ngezahayo A, Junghanss C, Murua Escobar H. Precursor B-ALL Cell Lines Differentially Respond to SYK Inhibition by Entospletinib. Int J Mol Sci. 2021 Jan 8;22(2):592. doi: 10.3390/ijms22020592

Uyar B, Palmer D, Kowald A, Murua Escobar H, Barrantes I, Möller S, Akalin A, Fuellen G. Single-cell analyses of aging, inflammation and senescence. Ageing Res Rev. 2020 Dec;64:101156. doi: 10.1016/j.arr.2020.101156

Völkner C, Liedtke M, Petters J, Huth K, Knuebel G, Murua Escobar H, Bullerdiek J, Lukas J, Hermann A, Frech MJ. Generation of an iPSC line (AKOSi006-A) from fibroblasts of an NPC1 patient, carrying the homozygous mutation p.I1061T (c.3182 T > C) and a control iPSC line (AKOSi007-A) using a non-integrating Sendai virus system. Stem Cell Res. 2020 Dec;49:102056. doi: 10.1016/j.scr.2020.102056

Petters J, Völkner C, Krohn S, Murua Escobar H, Bullerdiek J, Reuner U, Frech MJ, Hermann A, Lukas J. Generation of two induced pluripotent stem cell lines from a female adult homozygous for the Wilson disease associated ATP7B variant p.H1069Q (AKOSi008-A) and a healthy control (AKOSi009-A). Stem Cell Res. 2020 Dec;49:102079. doi: 10.1016/j.scr.2020.102079

Henze L, Walter U, Murua Escobar H, Junghanss C, Jaster R, Köhling R, Lange F, Salehzadeh-Yazdi A, Wolkenhauer O, Hamed M, Barrantes I, Palmer D, Möller S, Kowald A, Heussen N, Fuellen G. Towards biomarkers for outcomes after pancreatic ductal adenocarcinoma and ischaemic stroke, with focus on (co)-morbidity and ageing/cellular senescence (SASKit): protocol for a prospective cohort study. BMJ Open. 2020 Dec 17;10(12):e039560. doi: 10.1136/bmjopen-2020-039560

Völkner C, Liedtke M, Petters J, Lukas J, Murua Escobar H, Knuebel G, Bullerdiek J, Holzmann C, Hermann A, Frech MJ; US Food and Drug Administration Interviewees; Robyn Bent R, Bocell F, Garrard L, Johnson LL, Knoble N, Reasner D, Tarver M, Weinfurt K, Mullin T. Generation of an iPSC line (AKOSi004-A) from fibroblasts of a female adult NPC1 patient, carrying the compound heterozygous mutation p.Val1023Serfs*15/p.Gly992Arg and of an iPSC line (AKOSi005-A) from a female adult control individual. Stem Cell Res. 2020 Dec 15;50:102127. doi: 10.1016/j.scr.2020.102127

Grunwald L, Grosse-Thie C, Sender S, Knuebel G, Krohn S, Roolf C, Junghanss C, Henze L, Murua Escobar H. Ultradeep targeted sequencing reveals low allele frequencies of somatic JAK2 and MPL variants in patients with abdominal vein thromboses: results of an ongoing prospective prevalence study in Mecklenburg-West Pomerania. Biomark Res. 2020 Dec 14;8(1):73. doi: 10.1186/s40364-020-00254-9

Koschmieder A, Stachs O, Kragl B, Stahnke T, Sterenczak KA, Henze L, Jünemann AG, Junghanss C, Guthoff RF, Murua Escobar H. Non-invasive detection of corneal sub-basal nerve plexus changes in multiple myeloma patients by confocal laser scanning microscopy. Biosci Rep. 2020 Oct 30;40(10):BSR20193563. doi: 10.1042/BSR20193563 

Kong W, Sender S, Perez SV, Sekora A, Ruetgen B, Junghanss C, Nolte I, Murua Escobar H. Pan- and Isoform-specific Inhibition of the Bromodomain and Extra-terminal Proteins and Evaluation of Synergistic Potential With Entospletinib in Canine Lymphoma. Anticancer Res. 2020 Jul;40(7):3781-3792. doi: 10.21873/anticanres.14367

Felser S, Behrens M, Lampe H, Henze L, Grosse-Thie C, Murua Escobar H, Rohde K, Albrecht I, Zschorlich V, Junghanss C. Motivation and preferences of cancer patients to perform physical training. Eur J Cancer Care (Engl). 2020 Jul;29(4):e13246. doi: 10.1111/ecc.13246

Möller S, Saul N, Cohen AA, Köhling R, Sender S, Murua Escobar H, Junghanss C, Cirulli F, Berry A, Antal P, Adler P, Vilo J, Boiani M, Jansen L, Repsilber D, Grabe HJ, Struckmann S, Barrantes I, Hamed M, Wouters B, Schoofs L, Luyten W, Fuellen G. Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids. Aging (Albany NY). 2020 Jul 7;12(13):12534-12581. doi: 10.18632/aging.103514

Liu W, Sender S, Kong W, Beck J, Sekora A, Bornemann-Kolatzki K, Schuetz E, Junghanss C, Brenig B, Nolte I, Murua Escobar H. Establishment and characterization of stable red, far-red (fR) and near infra-red (NIR) transfected canine prostate cancer cell lines. Cancer Cell Int. 2020 Apr 29;20:139. doi: 10.1186/s12935-020-01211-0

Lorke M, Willen M, Lucas K, Schille JT, Lüder Ripoli F, Willenbrock S, Beyerbach M, Wefstaedt P, Murua Escobar H, Nolte I. Effect of antioxidants, mitochondrial cofactors and omega-3 fatty acids on telomere length and kinematic joint mobility in young and old shepherd dogs - A randomized, blinded and placebo-controlled study. Res Vet Sci. 2020 Apr;129:137-153. doi: 10.1016/j.rvsc.2020.01.008

Petters J, Cimmaruta C, Iwanov K, Chang ML, Völkner C, Knuebel G, Murua Escobar H, Frech MJ, Hermann A, Rolfs A, Lukas J. Generation of induced pluripotent stem cell lines AKOSi002-A and AKOSi003-A from symptomatic female adults with Wilson disease. Stem Cell Res. 2020 Mar;43:101708. doi: 10.1016/j.scr.2020.101708

Packeiser EM, Hewicker-Trautwein M, Thiemeyer H, Mohr A, Junginger J, Schille JT, Murua Escobar H, Nolte I. Characterization of six canine prostate adenocarcinoma and three transitional cell carcinoma cell lines derived from primary tumor tissues as well as metastasis. PLoS One. 2020 Mar 13;15(3):e0230272. doi: 10.1371/journal.pone.0230272

Richter A, Sender S, Lenz A, Schwarz R, Hinz B, Knuebel G, Sekora A, Murua Escobar H, Junghanss C, Roolf C. Influence of Casein kinase II inhibitor CX-4945 on BCL6-mediated apoptotic signaling in B-ALL in vitro and in vivo. BMC Cancer. 2020 Mar 4;20(1):184. doi: 10.1186/s12885-020-6650-9

Granados-Soler JL, Bornemann-Kolatzki K, Beck J, Brenig B, Schütz E, Betz D, Junginger J, Hewicker-Trautwein M, Murua Escobar H, Nolte I. Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival. Sci Rep. 2020 Jan 22;10(1):1003. doi: 10.1038/s41598-020-57942-7